HRID1387114

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID24386

Thionyl chloride

Cl2OS

HCID10612994

6-benzyloxy-2-dimethylaminobenzo[b]thiophene

C17H17NOS

结构：O=C(O)c1ccc(CN2CCCC2)c([N+](=O)[O-])c1

HCID21182684

未命名化合物

PRODUCTS

生成物

结构：CN(C)c1sc2cc(OCc3ccccc3)ccc2c1C(=O)c1ccc(CN2CCCC2)c([N+](=O)[O-])c1

HCID21182666

未命名化合物

收率 70%

PROCEDURE

实验过程

The title compound was prepared in 70% yield by essentially following the procedures outlined in Example 39, Part B (except using thionyl chloride instead of oxalyl chloride) from 3-nitro-4-[(1-pyrrolidinyl)methyl]benzoic acid (Part C, above) and 6-benzyloxy-2-(dimethylamino)benzo[b]thiophene (Example 81, Part B).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-41964061540648ffbb9ee5c860693467
来源数据集: uspto-grants-2001_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06265575B1
来源说明: uspto-grants-2001_07

反应 SMILES

S(Cl)(Cl)=O.[N+:5]([C:8]1[CH:9]=[C:10]([CH:14]=[CH:15][C:16]=1[CH2:17][N:18]1[CH2:22][CH2:21][CH2:20][CH2:19]1)[C:11]([OH:13])=O)([O-:7])=[O:6].[CH2:23]([O:30][C:31]1[CH:32]=[CH:33][C:34]2[CH:38]=[C:37]([N:39]([CH3:41])[CH3:40])[S:36][C:35]=2[CH:42]=1)[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>>[N+:5]([C:8]1[CH:9]=[C:10]([C:11]([C:38]2[C:34]3[CH:33]=[CH:32][C:31]([O:30][CH2:23][C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=4)=[CH:42][C:35]=3[S:36][C:37]=2[N:39]([CH3:41])[CH3:40])=[O:13])[CH:14]=[CH:15][C:16]=1[CH2:17][N:18]1[CH2:22][CH2:21][CH2:20][CH2:19]1)([O-:7])=[O:6]