HRID1387116

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CN(C)c1cc(C(=O)c2c(N(C)C)sc3cc(OCc4ccccc4)ccc23)ccc1CN1CCCC1

HCID21182635

未命名化合物

HCID178419640

未命名化合物

PRODUCTS

生成物

结构：CN(C)c1cc(C(=O)c2c(-c3ccc(OCCN4CCCC4)cc3)sc3cc(OCc4ccccc4)ccc23)ccc1CN1CCCC1

HCID21182796

未命名化合物

收率 79%

PROCEDURE

实验过程

The title compound was prepared in 79% yield by essentially following the procedures outlined in Example 81, Part E, from 6-benzyloxy-2-(dimethylamino)benzo[b]thiophen-3-yl 3-(dimethylamino)-4-(1-pyrrolidinylmethyl)phenyl ketone (Part F) and 4-[2-(1-pyrrolidinyl)ethoxy]phenyl magnesium bromide (Example 81, Part D).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-a87f84e7817d4d899203f33cfd5a22a8
来源数据集: uspto-grants-2001_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06265575B1
来源说明: uspto-grants-2001_07

反应 SMILES

[CH3:1][N:2]([CH3:37])[C:3]1[CH:4]=[C:5]([C:15]([C:17]2[C:18]3[CH:28]=[CH:27][C:26]([O:29][CH2:30][C:31]4[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=4)=[CH:25][C:19]=3[S:20][C:21]=2N(C)C)=[O:16])[CH:6]=[CH:7][C:8]=1[CH2:9][N:10]1[CH2:14][CH2:13][CH2:12][CH2:11]1.[N:38]1([CH2:43][CH2:44][O:45][C:46]2[CH:51]=[CH:50][C:49]([Mg]Br)=[CH:48][CH:47]=2)[CH2:42][CH2:41][CH2:40][CH2:39]1>>[CH3:1][N:2]([CH3:37])[C:3]1[CH:4]=[C:5]([C:15]([C:17]2[C:18]3[CH:28]=[CH:27][C:26]([O:29][CH2:30][C:31]4[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=4)=[CH:25][C:19]=3[S:20][C:21]=2[C:49]2[CH:48]=[CH:47][C:46]([O:45][CH2:44][CH2:43][N:38]3[CH2:39][CH2:40][CH2:41][CH2:42]3)=[CH:51][CH:50]=2)=[O:16])[CH:6]=[CH:7][C:8]=1[CH2:9][N:10]1[CH2:14][CH2:13][CH2:12][CH2:11]1