HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Benzyloxy-2-(dimethylamino)benzo[b]thiophen-3-yl 3-(dimethylamino)-4-(1-pyrrolidinylmethyl)phenyl ketone → 6-Benzyloxy-2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]benzo[b]thiophen-3-yl 3-(Dimethylamino)-4-(1-pyrrolidinylmethyl)phenyl Ketone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Benzyloxy-2-(dimethylamino)benzo[b]thiophen-3-yl 3-(dimethylamino)-4-(1-pyrrolidinylmethyl)phenyl ketone | HCID 21182635 | — |
| Reactant | HCID 178419640 | HCID 178419640 | — |
| Product | 6-Benzyloxy-2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]benzo[b]thiophen-3-yl 3-(Dimethylamino)-4-(1-pyrrolidinylmethyl)phenyl Ketone | HCID 21182796 | 79% |
Reaction Steps
The title compound was prepared in 79% yield by essentially following the procedures outlined in Example 81, Part E, from 6-benzyloxy-2-(dimethylamino)benzo[b]thiophen-3-yl 3-(dimethylamino)-4-(1-pyrrolidinylmethyl)phenyl ketone (Part F) and 4-[2-(1-pyrrolidinyl)ethoxy]phenyl magnesium bromide (Example 81, Part D).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06265575B1 |
| Source dataset | uspto-grants-2001_07 |
| ORD ID | ord-a87f84e7817d4d899203f33cfd5a22a8 |
| Source note | uspto-grants-2001_07 |