HRID1387123

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID21182755

未命名化合物

结构：COc1cc(C(=O)c2c(N(C)C)sc3cc(OCc4ccccc4)ccc23)ccc1CN1CCOCC1

HCID22462787

未命名化合物

PRODUCTS

生成物

结构：COc1cc(C(=O)c2c(-c3ccc(OCCN4CCCC4)c(COCc4ccccc4)c3)sc3cc(OCc4ccccc4)ccc23)ccc1CN1CCOCC1

HCID21182876

未命名化合物

收率 11%

PROCEDURE

实验过程

The title compound was prepared in 11% yield by essentially following the procedures outlined in Example 81, Part E, from 6-benzyloxy-2-(dimethylamino)benzo[b]thiophen-3-yl 3-methoxy-4-[(4-morpholinyl)methyl]phenyl ketone (Example 49, Part C) and 1-[2-(2-benzyloxymethyl-4-bromophenoxy)ethyl]pyrrolidine (Part A).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-58f9242ffc1c4a2dae02f0d8b9e27460
来源数据集: uspto-grants-2001_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06265575B1
来源说明: uspto-grants-2001_07

反应 SMILES

[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:16]([C:18]2[C:19]3[CH:29]=[CH:28][C:27]([O:30][CH2:31][C:32]4[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=4)=[CH:26][C:20]=3[S:21][C:22]=2N(C)C)=[O:17])[CH:6]=[CH:7][C:8]=1[CH2:9][N:10]1[CH2:15][CH2:14][O:13][CH2:12][CH2:11]1.[CH2:38]([O:45][CH2:46][C:47]1[CH:60]=[C:59](Br)[CH:58]=[CH:57][C:48]=1[O:49][CH2:50][CH2:51][N:52]1[CH2:56][CH2:55][CH2:54][CH2:53]1)[C:39]1[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=1>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:16]([C:18]2[C:19]3[CH:29]=[CH:28][C:27]([O:30][CH2:31][C:32]4[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=4)=[CH:26][C:20]=3[S:21][C:22]=2[C:59]2[CH:58]=[CH:57][C:48]([O:49][CH2:50][CH2:51][N:52]3[CH2:53][CH2:54][CH2:55][CH2:56]3)=[C:47]([CH2:46][O:45][CH2:38][C:39]3[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=3)[CH:60]=2)=[O:17])[CH:6]=[CH:7][C:8]=1[CH2:9][N:10]1[CH2:15][CH2:14][O:13][CH2:12][CH2:11]1