HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-[2-(2-Benzyloxymethyl-4-bromophenoxy)ethyl]pyrrolidine → 6-Benzyloxy-2-[3-benzyloxymethyl-4-[2-(1-pyrrolidinyl)ethoxy]phenyl]benzo[b]thiophen-3-yl 3-Methoxy-4-(4-morpholinylmethyl)phenyl Ketone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-[2-(2-Benzyloxymethyl-4-bromophenoxy)ethyl]pyrrolidine | HCID 21182755 | — |
| Reactant | 6-Benzyloxy-2-(dimethylamino)benzo[b]thiophen-3-yl 3-methoxy-4-[(4-morpholinyl)methyl]phenyl ketone | HCID 22462787 | — |
| Product | 6-Benzyloxy-2-[3-benzyloxymethyl-4-[2-(1-pyrrolidinyl)ethoxy]phenyl]benzo[b]thiophen-3-yl 3-Methoxy-4-(4-morpholinylmethyl)phenyl Ketone | HCID 21182876 | 11% |
Reaction Steps
The title compound was prepared in 11% yield by essentially following the procedures outlined in Example 81, Part E, from 6-benzyloxy-2-(dimethylamino)benzo[b]thiophen-3-yl 3-methoxy-4-[(4-morpholinyl)methyl]phenyl ketone (Example 49, Part C) and 1-[2-(2-benzyloxymethyl-4-bromophenoxy)ethyl]pyrrolidine (Part A).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06265575B1 |
| Source dataset | uspto-grants-2001_07 |
| ORD ID | ord-58f9242ffc1c4a2dae02f0d8b9e27460 |
| Source note | uspto-grants-2001_07 |