反应详情

1.14 g (10.2 mmol) of histamine base and 1.62 g (10.2 mmol) of 2-chloro-3-nitropyridine are brought to reflux in 5 ml of 2-propanol for 3 h. Evaporation of the solvent under reduced pressure and purification of the solid residue by chromatography on a column of silica gel, eluted with chloroform containing increasing amounts of methanol (5, 10 and 20%), provide the title compound. M.p.: 178°-180° C. (yield 65%; ethanol:water).

1. customEvaporation of the solvent
2. customunder reduced pressure and purification of the solid residue by chromatography on a column of silica gel
3. washeluted with chloroform containing
4. temperatureincreasing amounts of methanol (5, 10 and 20%)