Carbonate Ion → HCID 21715611, compound

HRID 1387218Notes

Reaction equation

HRID 1387218 reaction equation
C(=O)([O-])[O-].[CH3:5][O:6][C:7]1[CH:12]=[C:11]([O:13][CH3:14])[N:10]=[C:9]([O:15][C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([OH:22])[C:17]=2[C:23]2[O:27][CH:26]=[N:25][CH:24]=2)[N:8]=1.Cl[N:29]1[N:34]=[C:33]([O:35][CH3:36])[CH:32]=[C:31]([O:37][CH3:38])[NH:30]1>CN(C=O)C>[CH3:14][O:13][C:11]1[CH:12]=[C:7]([O:6][CH3:5])[N:8]=[C:9]([O:15][C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([O:22][N:29]3[N:30]=[C:31]([O:37][CH3:38])[CH:32]=[C:33]([O:35][CH3:36])[NH:34]3)[C:17]=2[C:23]2[O:27][CH:26]=[N:25][CH:24]=2)[N:10]=1

Participants

5

Reactant 3

HCID 19660Carbonate IonHCID 21715621HCID 21715621, compoundHCID 221477162-Chloro-4,6-dimethoxy-triazine

Product 1

HCID 21715611HCID 21715611, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent2×

Procedure

To DMF solution containing 0.14 g pottasium carbonate and 0.15 g 5-[2-(4,6-dimethoxypyrimidine-2-yloxy)-6-hydroxyphenyl]oxazole, was added at once DMF solution containing 0.13 g 2-chloro-4,6-dimethoxytriazine. The solution reacted was stirred for a night at room temperature. After completing the reaction, the solution reacted was poured into ice water and then extracted with ethyl acetate. The organic layer obtained was washed with water and saturated saline solution in turn and was then dried by using anhydrous magnesium sulfate. The solvent used was removed by distillation under reduced pressure, affording the objective substance in an amount of 0.22 g.

Workup

  1. customThe solution reacted
  2. customthe reaction
  3. customthe solution reacted
  4. extractionextracted with ethyl acetate
  5. customThe organic layer obtained
  6. washwas washed with water and saturated saline solution in turn
  7. customwas then dried
  8. customThe solvent used was removed by distillation under reduced pressure
  9. customaffording the objective substance in an amount of 0.22 g

Sources & evidence

ORD record
ord-e16de906b93d4125bca0c2bd76681839
Source dataset
uspto-grants-2001_07
Patent number
US06268310B1

Reaction notes

Loading…