HCID 15884981, compound → HCID 15884982, compound

HRID 1387262Notes

Reaction equation

HRID 1387262 reaction equation
[CH2:1]([N:8]([CH2:10][C:11]1[C:20]([CH3:21])=[CH:19][CH:18]=[C:17]2[C:12]=1[NH:13][C:14](=[O:23])[C:15](=[O:22])[NH:16]2)C)C1C=CC=CC=1>CN(C=O)C.[Pd]>[CH3:21][C:20]1[C:11]([CH2:10][NH:8][CH3:1])=[C:12]2[C:17](=[CH:18][CH:19]=1)[NH:16][C:15](=[O:22])[C:14](=[O:23])[NH:13]2

Participants

4

Reactant 1

HCID 15884981HCID 15884981, compound

Product 1

HCID 15884982HCID 15884982, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 6228DimethylformamideSolvent2×

Procedure

A solution of 5-[(benzyl-methyl-amino)-methyl]-6-methyl-1,4-dihydro-quinoxaline-2,3-dione (3.23 g, 10.45 mmol) in DMF (100 mL) was hydrogenated (Pd/C, 20%, 0.5 g) in DMF (100 mL). The suspension was filtered, and the filtrate was evaporated to give a solid, which was crystallized from methanol.

Workup

  1. filtrationThe suspension was filtered
  2. customthe filtrate was evaporated
  3. customto give a solid, which
  4. customwas crystallized from methanol

Sources & evidence

ORD record
ord-928e356807b7449b8222f53d8da1dfe6
Source dataset
uspto-grants-2001_07
Patent number
US06268366B1

Reaction notes

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