4-Methylbenzyl chloride → HCID 23665764, compound

HRID 1387265Notes

Reaction equation

HRID 1387265 reaction equation
[S:1]([O-:4])([O-:3])=[O:2].[Na+:5].[Na+].[CH3:7][C:8]1[CH:15]=[CH:14][C:11]([CH2:12]Cl)=[CH:10][CH:9]=1>O>[Na+:5].[CH3:7][C:8]1[CH:15]=[CH:14][C:11]([CH2:12][S:1]([O-:4])(=[O:3])=[O:2])=[CH:10][CH:9]=1

Participants

4

Reactant 2

HCID 77224-Methylbenzyl chlorideHCID 24437Sodium Sulfite

Product 1

HCID 23665764HCID 23665764, compoundYield 53%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a solution of sodium sulfite (14.3 g, 113 mmol) in water (60 mL) was added 4-methylbenzyl chloride (15.0 ml,, i13 mmol). The mixture was stirred under reflux for 12 hours, and cooled to rt. The precipitate was collected by filtration, and washed with water and ether to give 4-methylphenylmethanesulfonic acid sodium salt (12.5 g, 60 mmol, 53%).

Workup

  1. temperatureunder reflux for 12 hours
  2. filtrationThe precipitate was collected by filtration
  3. washwashed with water and ether

Sources & evidence

ORD record
ord-cb932c1d5fde42c1b80dd050d0292953
Source dataset
uspto-grants-2001_07
Patent number
US06268365B1

Reaction notes

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