反应详情

A mixture of 5-iodo-4-methyl-3-nitro-2-pyridone (2.90 g, 10.4 mmol) and sodium hydride (60% in oil, 0.44 g, 11 mmol) was stirred at rt for 2.5 hours. 4-Methoxybenzyl chloride (1.50 mL) was added, and the mixture was stirred at rt for 18 h. Water was added, and the l s mixture and extracted with ethyl acetate. The organic phase was washed, dried and evaporated. Chromatography of the residue over silica gel (35% ethyl acetate/petroleum ether) followed by crystallization from water gave 1-(4-methoxybenzyl)-5-iodo-4-methyl-3-nitro-2-pyridone (3.11 g, 75%).

1. stirringthe mixture was stirred at rt for 18 h
2. extractionextracted with ethyl acetate
3. washThe organic phase was washed
4. customdried
5. customevaporated
6. customChromatography of the residue over silica gel (35% ethyl acetate/petroleum ether) followed by crystallization from water