Water → HCID 18670812, compound

HRID 1387323Notes

Reaction equation

HRID 1387323 reaction equation
[C:1]1([CH:11]=O)[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.[Cl:13]C(Cl)C(OC)=O.C[C:21](C)([O-:23])C.[K+].[OH2:26].[C:27]([OH:31])([CH3:30])(C)C>CCCCCC.C(OCC)(=O)C>[Cl:13][CH:11]([C:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1)[C:27](=[O:31])[C:30]([O:23][CH3:21])=[O:26]

Participants

7

Reactant 5

HCID 962WaterHCID 61951-NaphthaldehydeHCID 6386tert-ButanolHCID 8315Methyl dichloroacetateHCID 23665647Potassium tert-butoxide

Product 1

HCID 18670812HCID 18670812, compoundYield 19%

Reagents, catalysts & solvents 1

HCID 21226206Ethyl acetate hexaneSolvent

Procedure

7.80 g(49.9 mmol) of 1-naphthaldehyde and 7.15 g(49.9 mmol) of methyl dichloroacetate were dissolved in 100 ml of t-butanol, and 6.15 g(54.8 mmol) of potassium t-butoxide was added thereto at 0° C. The mixture was stirred at room temperature for 24 hours and then 50 ml of water was added to stop the reaction. The solvent was removed under reduced pressure and the residue was extracted with ethyl acetate. The organic layer was dried over magnesium sulfate, concentrated and subjected to silica gel column chromatography(eluent: n-hexane/ethyl acetate=90/10, v/v) to give 2.5 g(9.52 mmol, Yield 19%) of the title compound.

Workup

  1. customat 0° C
  2. customthe reaction
  3. customThe solvent was removed under reduced pressure
  4. extractionthe residue was extracted with ethyl acetate
  5. dry with materialThe organic layer was dried over magnesium sulfate
  6. concentrationconcentrated

Sources & evidence

ORD record
ord-96dcdea131704fb693e44a8f29ca0c6b
Source dataset
uspto-grants-2001_07
Patent number
US06268363B1

Reaction notes

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