反应详情

To a cold (10° C.) solution of 12.6 g (0.11 mole) of methanesulfonyl chloride and 10.3 g (0.13 mole) of triethylamine was added dropwise 15.8 g of 2-ethyl-2-(hydroxymethyl)hexanal, prepared according to the procedure described in Chem. Ber. 98, 728-734 (1965), while maintaining the reaction temperature below 30° C. The reaction mixture was stirred at room temperature for 18 h, quenched with dilute HCl and extracted with methlyene chloride. The methylene chloride extract was dried over MgSO4 and concentrated in vacuo to give 24.4 g of brown oil.

1. customprepared
2. temperature98, 728-734 (1965), while maintaining the reaction temperature below 30° C
3. customquenched with dilute HCl
4. extractionextracted with methlyene chloride
5. extractionThe methylene chloride extract
6. dry with materialwas dried over MgSO4
7. concentrationconcentrated in vacuo