4-Bromophenol → HCID 11551054, compound

HRID 1387487Notes

Reaction equation

HRID 1387487 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.[CH3:9][O:10][C:11]1[CH:12]=[C:13]([CH:16]=[CH:17][CH:18]=1)[CH2:14]Cl>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[C:4]([CH2:14][C:13]2[CH:16]=[CH:17][CH:18]=[C:11]([O:10][CH3:9])[CH:12]=2)[CH:3]=1

Participants

3

Reactant 2

HCID 78084-BromophenolHCID 699943-Methoxybenzyl chloride

Product 1

HCID 11551054HCID 11551054, compound

Procedure

Alkylation of 4-bromophenol with 3-methoxybenzyl chloride according to the procedure described in J. Chem. Soc, 2431 (1958) gave 4-bromo-2-(3′-methoxybenzyl)phenol. This material was converted to compound 75, mp 97-101.5° C., and compound 76, mp 102-106° C., by the procedure similar to that in Example 18 method B.

Sources & evidence

ORD record
ord-63b9f20323aa4466bce6e168ccb554b5
Source dataset
uspto-grants-2001_07
Patent number
US06268392B1

Reaction notes

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