4-Fluorobenzyl chloride → 4-Fluoro-2-[(4-fluorophenyl)methyl]phenol

HRID 1387488Notes

Reaction equation

[F:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.[F:9][C:10]1[CH:17]=[CH:16][C:13]([CH2:14]Cl)=[CH:12][CH:11]=1>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[C:4]([CH2:14][C:13]2[CH:16]=[CH:17][C:10]([F:9])=[CH:11][CH:12]=2)[CH:3]=1

Participants

Reactant 2

HCID 96024-Fluorobenzyl chloride

HCID 97324-Fluorophenol

Product 1

HCID 223252574-Fluoro-2-[(4-fluorophenyl)methyl]phenol

Procedure

Alkylation of 4-fluorophenol with 4-fluorobenzyl chloride according to the procedure described in J. Chem. Soc, 2431 (1958) gave 4-fluoro-2-(4′-fluorobenzyl)phenol. This material was converted to compound 77, mp 228-230° C., and compound 78, mp 134.5-139° C., by the procedure similar to that in Example 18 method B.

Sources & evidence

ORD record: ord-ad4a2acada0c4f7790ba9445d25242f3
Source dataset: uspto-grants-2001_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06268392B1

Reaction notes

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