m-Tolylisothiocyanate → HCID 54422588, compound

HRID 1387562Notes

Reaction equation

HRID 1387562 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([CH:16]=[CH:17][C:18]=1[O:19][CH3:20])[C:5]([NH:7][C:8]1[CH:13]=[C:12]([CH3:14])[CH:11]=[C:10]([CH3:15])[CH:9]=1)=[O:6].[CH3:21][C:22]1[CH:23]=[C:24]([N:28]=[C:29]=[S:30])[CH:25]=[CH:26][CH:27]=1>>[CH3:15][C:10]1[CH:9]=[C:8]([NH:7][C:5](=[O:6])[C:4]2[CH:16]=[CH:17][C:18]([O:19][CH3:20])=[C:2]([NH:1][C:29]([NH:28][C:24]3[CH:23]=[C:22]([CH3:21])[CH:27]=[CH:26][CH:25]=3)=[S:30])[CH:3]=2)[CH:13]=[C:12]([CH3:14])[CH:11]=1

Participants

3

Reactant 2

HCID 69304m-TolylisothiocyanateHCID 167939593-Amino-4-methoxy-N-(3,5-dimethylphenyl)-benzamide

Product 1

HCID 54422588HCID 54422588, compoundYield 48.6%

Procedure

Prepared according to the procedure described for Example 102 using 3-amino-N-(3,5-dimethylphenyl)-4-methoxy-benzamide from Example 11 (0.542 g, 2.01 mmol) and 3-methylphenyl isothiocyanate (0.28 mL, 2.07 mmol) to afford the product (0.41 g); m.p. 188-189° C.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-1cc86f372ede4ec3bc0f521ed2e50f77
Source dataset
uspto-grants-2001_07
Patent number
US06268387B1

Reaction notes

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