Hydrochloric Acid → HCID 18626291, compound

HRID 1387575Notes

Reaction equation

HRID 1387575 reaction equation
N1C=CC=CC=1.[F:7][C:8]([F:20])([F:19])[C:9]1[CH:14]=[CH:13][C:12]([S:15](Cl)(=[O:17])=[O:16])=[CH:11][CH:10]=1.[NH2:21][C:22]1[CH:23]=[C:24]([CH:34]=[CH:35][C:36]=1[O:37][CH3:38])[C:25]([NH:27][C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)=[O:26].Cl>O>[F:7][C:8]([F:20])([F:19])[C:9]1[CH:14]=[CH:13][C:12]([S:15]([NH:21][C:22]2[CH:23]=[C:24]([CH:34]=[CH:35][C:36]=2[O:37][CH3:38])[C:25]([NH:27][C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)=[O:26])(=[O:17])=[O:16])=[CH:11][CH:10]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 1049PyridineHCID 84263-Amino-4-methoxybenzanilideHCID 27773994-(Trifluoromethyl)benzenesulfonyl chloride

Product 1

HCID 18626291HCID 18626291, compoundYield 88.8%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Pyridine (5 mL) was added to a mixture of 4-trifluoromethylbenzenesulfonyl chloride (0.73 g, 3.0 mmol) and 3-amino-4-methoxy-N-phenyl-benzamide (0.73 g, 3.0 mmol) and stirred at room temperature. After 20 hours, the mixture was added to water (50 mL), acidified with 2N HCl, and stirred for an hour. The precipitate was filtered off, rinsed with water, and dried to afford the product (1.2 g); m.p. 197-198° C.

Workup

  1. stirringstirred for an hour
  2. filtrationThe precipitate was filtered off
  3. washrinsed with water
  4. customdried

Sources & evidence

ORD record
ord-d1c6cfb64b084f4ab623d05cecfff644
Source dataset
uspto-grants-2001_07
Patent number
US06268387B1

Reaction notes

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