Phosphorus oxychloride → HCID 178466708, compound

HRID 1387672Notes

Reaction equation

HRID 1387672 reaction equation
O[C:2]1[NH:11][C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]2[C:12](=[O:25])[N:13]([C:16]3[CH:21]=[CH:20][C:19]([O:22][CH2:23][CH3:24])=[CH:18][CH:17]=3)[C:14](=[O:15])[C:3]=12.P(Cl)(Cl)([Cl:28])=O>>[Cl:28][C:2]1[NH:11][C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]2[C:12](=[O:25])[N:13]([C:16]3[CH:21]=[CH:20][C:19]([O:22][CH2:23][CH3:24])=[CH:18][CH:17]=3)[C:14](=[O:15])[C:3]=12

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 178466710HCID 178466710, compound

Product 1

HCID 178466708HCID 178466708, compound

Procedure

A solution of 4-Hydroxy-2-(4-ethoxyphenyl)-imidazo[1,5,a]-quinoxaline-1,3(2H,5H)-dione (3.2 g) in phosphorous oxychloride (40 mL) was refluxed for 16 h. The solvent was removed in vacuo and water (15 mL) was added. The pH was adjusted to 7.0 using ammonium hydroxide and this resulting solid was filtered and dried to yield 4-Chloro-2-(4-ethoxyphenyl)-imidazo[1,5,a]quinoxaline-1,3(2H,5H)-dione (Compound 36).

Workup

  1. customThe solvent was removed in vacuo and water (15 mL)
  2. additionwas added
  3. filtrationthis resulting solid was filtered
  4. customdried

Sources & evidence

ORD record
ord-844cbbc1f8d1496386d228691392aca5
Source dataset
uspto-grants-2001_07
Patent number
US06268496B1

Reaction notes

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