Ammonia → HCID 178466709, compound

HRID 1387673Notes

Reaction equation

HRID 1387673 reaction equation
N.Cl[C:3]1[NH:12][C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]2[C:13](=[O:26])[N:14]([C:17]3[CH:22]=[CH:21][C:20]([O:23][CH2:24][CH3:25])=[CH:19][CH:18]=3)[C:15](=[O:16])[C:4]=12>C1COCC1>[CH2:24]([O:23][C:20]1[CH:19]=[CH:18][C:17]([N:14]2[C:15](=[O:16])[C:4]3=[CH:3][NH:12][C:11]4[C:6]([N:5]3[C:13]2=[O:26])=[CH:7][CH:8]=[CH:9][CH:10]=4)=[CH:22][CH:21]=1)[CH3:25]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 178466708HCID 178466708, compound

Product 1

HCID 178466709HCID 178466709, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of THF (10 mL), ammonia (10 mL) and 4-Chloro-2-(4-ethoxyphenyl)-imidazo[1,5,a]quinoxaline-1,3(2H,5H)-dione (100 mg) was heated to 100IC in a sealed tube for 4 hours. After cooling to room temperature the solvent was removed in vacuo. The solid was slurried in 50% EtOH—H2O and filtered to yield 4-Amino-2-(4-ethoxyphenyl-imidazo[1,5,a]quinoxaline-1,3(2H,5H)-dione (Compound 37).

Workup

  1. customwas removed in vacuo
  2. filtrationfiltered

Sources & evidence

ORD record
ord-30448bc58f7b49ec8bd2013c262c685e
Source dataset
uspto-grants-2001_07
Patent number
US06268496B1

Reaction notes

Loading…