Potassium Carbonate → HCID 11167655, compound

HRID 1387744Notes

Reaction equation

HRID 1387744 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][C@@H:12]([O:14][CH2:15][CH3:16])[C@H:11]([C:17]2[CH:22]=[CH:21][C:20]([OH:23])=[CH:19][CH:18]=2)[C@@H:10]([OH:24])[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].Br[C:26]1[CH:27]=[C:28]([CH2:32][O:33][CH2:34][CH2:35][CH3:36])[CH:29]=[CH:30][CH:31]=1.C(=O)([O-])[O-].[K+].[K+]>>[C:1]([O:5][C:6]([N:8]1[CH2:13][C@@H:12]([O:14][CH2:15][CH3:16])[C@H:11]([C:17]2[CH:22]=[CH:21][C:20]([O:23][CH2:36][CH2:35][CH2:34][O:33][CH2:32][C:28]3[CH:29]=[CH:30][CH:31]=[CH:26][CH:27]=3)=[CH:19][CH:18]=2)[C@@H:10]([OH:24])[CH2:9]1)=[O:7])([CH3:2])([CH3:3])[CH3:4]

Participants

4

Reactant 3

HCID 11430Potassium CarbonateHCID 11450566HCID 11450566, compoundHCID 57057286HCID 57057286, compound

Product 1

HCID 11167655HCID 11167655, compound

Procedure

treating the product of step e) with 3-bromo-propoxymethyl-benzene and potassium carbonate to yield (3R,4R,5S)-4-[4-(3-benzyloxy-propoxy)-phenyl]-5-ethoxy-3-hydroxy-piperidine-1-carboxylic acid tert-butylester;

Sources & evidence

ORD record
ord-0d6e6f0d53f546ed8915d74511efbb99
Source dataset
uspto-grants-2001_07
Patent number
US06268499B1

Reaction notes

Loading…