Methyl iodide → HCID 86756159, compound

HRID 1387852Notes

Reaction equation

HRID 1387852 reaction equation
[C:1]1([C:7]2[CH:8]=[C:9]([CH:28]=[CH:29][CH:30]=2)[CH:10]=[CH:11][C:12]([NH:14][C:15]2[CH:27]=[CH:26][C:18]([CH2:19][N:20]3[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]3)=[CH:17][CH:16]=2)=[O:13])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:31][I:32]>CN(C)C=O>[I-:32].[CH3:31][N+:20]1([CH2:19][C:18]2[CH:17]=[CH:16][C:15]([NH:14][C:12](=[O:13])[CH:11]=[CH:10][C:9]3[CH:28]=[CH:29][CH:30]=[C:7]([C:1]4[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=4)[CH:8]=3)=[CH:27][CH:26]=2)[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 53970337HCID 53970337, compound

Product 1

HCID 86756159HCID 86756159, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A solution of 1-(4-(3-phenylcinnamoylamino)-benzyl)piperidine (0.32 g) and methyl iodide (0.15 ml) in dimethylformamide (5 ml) was stirred over night under nitrogen atmosphere at room temperature. The solvent was evaporated, and to the residue was added ethyl acetate. Precipitated crude crystal was filtered, which were recrystallized from ethanol to give 1-methyl-1-(4-(3-phenylcinnamoylamino)-benzyl)piperidinium iodide (Compound 85) (0.26 g) as colorless crystals.

Workup

  1. customThe solvent was evaporated
  2. additionto the residue was added ethyl acetate
  3. customPrecipitated crude crystal
  4. filtrationwas filtered
  5. customwhich were recrystallized from ethanol

Sources & evidence

ORD record
ord-4ab374876ae84213b3dbc107387dabb8
Source dataset
uspto-grants-2001_07
Patent number
US06268354B1

Reaction notes

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