Diethyl benzylphosphonate → Benzylphosphonic Acid

HRID 1387921Notes

Reaction equation

HRID 1387921 reaction equation
[CH2:1]([P:8](=[O:15])([O:12]CC)[O:9]CC)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>CO.Cl>[CH2:1]([P:8](=[O:9])([OH:15])[OH:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 1

HCID 14122Diethyl benzylphosphonate

Product 1

HCID 81312Benzylphosphonic AcidYield 59.2%

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 887MethanolSolvent

Procedure

A solution of diethyl benzylphosphonate (25 g) in methanol (10 ml) and concentrated hydrochloric acid (500 ml) solution was refluxed for 4 days. The mixture was cooled to room temperature, and precipitated crystal was collected by filtration to give benzylphosphonic acid (11.17 g) as colorless crystals.

Workup

  1. customprecipitated crystal
  2. filtrationwas collected by filtration

Sources & evidence

ORD record
ord-d5583e0ceee54d63822d72c53eaff463
Source dataset
uspto-grants-2001_07
Patent number
US06268354B1

Reaction notes

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