Methyl iodide → HCID 21715697, compound

HRID 1387982Notes

Reaction equation

HRID 1387982 reaction equation
[CH3:1][N:2]([CH2:9][C:10]1[CH:15]=[CH:14][C:13]([NH:16][C:17](=[O:34])/[CH:18]=[CH:19]/[C:20]2[S:21][C:22]([C:25]3[CH:30]=[CH:29][C:28]([CH:31]([CH3:33])[CH3:32])=[CH:27][CH:26]=3)=[CH:23][CH:24]=2)=[CH:12][CH:11]=1)[CH:3]1[CH2:8][CH2:7][O:6][CH2:5][CH2:4]1.[CH3:35][I:36]>CN(C=O)C>[I-:36].[CH3:1][N+:2]([CH:3]1[CH2:8][CH2:7][O:6][CH2:5][CH2:4]1)([CH3:35])[CH2:9][C:10]1[CH:11]=[CH:12][C:13]([NH:16][C:17](=[O:34])/[CH:18]=[CH:19]/[C:20]2[S:21][C:22]([C:25]3[CH:26]=[CH:27][C:28]([CH:31]([CH3:32])[CH3:33])=[CH:29][CH:30]=3)=[CH:23][CH:24]=2)=[CH:14][CH:15]=1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 18472312HCID 18472312, compound

Product 1

HCID 21715697HCID 21715697, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a solution of (E)-N-[4-[N-methyl-N-(tetrahydro-pyran-4-yl)aminomethyl]phenyl]-3-[5-(4-isopropylphenyl)thiophen-2-yl]acrylamide (80 mg) in DMF (5 ml) was added at room temperature methyl iodide (0.04 ml), and the mixture was stirred for 3 days. Under reduced pressure, the solvent was evaporated, and to the residue was added acetonitrile. The resulting crystals were collected by filtration to give yellow crystals of N,N-dimethyl-N-[4-[[(E)-3-[5-(4-isopropylphenyl)thiophen-2-yl]-2-propenoyl]amino]benzyl]-4-tetrahydropyranyl ammonium iodide (Compound 280) (76.9 mg).

Workup

  1. customUnder reduced pressure, the solvent was evaporated
  2. additionto the residue was added acetonitrile
  3. filtrationThe resulting crystals were collected by filtration

Sources & evidence

ORD record
ord-bb071e57a85d463f9b7b0a278d918098
Source dataset
uspto-grants-2001_07
Patent number
US06268354B1

Reaction notes

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