反应详情

In trifluoroacetic acid (7 ml) was dissolved the above t-butyloxycarbonyl-α-aminoisobutyroyl-D-isoglutamine benzyl ester (632 mg, 1.5 m mols) and the reaction was conducted at room temperature for 30 minutes. The solvent was distilled off and diethyl ether was added to the residue. The precipitated α-aminoisobutyroyl-D-isoglutamine benzyl ester trifluoroacetate was recovered by filtration. It was dissolved in tetrahydrofuran (10 ml) and, under ice-cooling neutralized with triethylamine (0.21 ml). By the above procedure there was obtained a solution of α-aminoisobutyroyl-D-isoglutamine benzyl ester in tetrahydrofuran.

1. distillationThe solvent was distilled off
2. additiondiethyl ether was added to the residue
3. filtrationThe precipitated α-aminoisobutyroyl-D-isoglutamine benzyl ester trifluoroacetate was recovered by filtration
4. dissolutionIt was dissolved in tetrahydrofuran (10 ml) and, under ice-
5. temperaturecooling