Formaldehyde → HCID 54335010, compound

HRID 1388131Notes

Reaction equation

HRID 1388131 reaction equation
[CH2:1]([O:3][C:4](=[O:19])[CH:5]([CH2:9][CH2:10][CH2:11][CH2:12][CH:13]1[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]1)[C:6](O)=O)[CH3:2].C=O.N1CCCCC1>N1C=CC=CC=1>[CH2:1]([O:3][C:4](=[O:19])[C:5](=[CH2:6])[CH2:9][CH2:10][CH2:11][CH2:12][CH:13]1[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18]1)[CH3:2]

Participants

5

Reactant 3

HCID 712FormaldehydeHCID 8082PiperidineHCID 53870239HCID 53870239, compound

Product 1

HCID 54335010HCID 54335010, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

16.6 g of 6-cyclohexyl-2-methylenehexanoic acid ethyl ester, in the form of a nearly colourless oil, which is purified by chromatography on silica gel (migrating agent: 80:20 petroleum ether/ethyl acetate), are obtained by the procedure described in Example (1b) from 26 g of (4-cyclohexylbutyl)-malonic acid ethyl ester, 3.1 g of paraformaldehyde, 19 ml of pyridine and 1.2 ml of piperidine.

Workup

  1. custom16.6 g of 6-cyclohexyl-2-methylenehexanoic acid ethyl ester, in the form of a nearly colourless oil, which is purified by chromatography on silica gel (migrating agent: 80:20 petroleum ether/ethyl acetate)
  2. customare obtained by the procedure

Sources & evidence

ORD record
ord-73ef239690f5471d95775e76bfeb85a4
Source dataset
uspto-grants-1984_02
Patent number
US04430339

Reaction notes

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