Formaldehyde → HCID 53689540, compound

HRID 1388136Notes

Reaction equation

HRID 1388136 reaction equation
[CH2:1]([O:3][C:4](=[O:22])[CH:5]([CH2:9][CH2:10][CH2:11][CH2:12][O:13][CH2:14][CH2:15][CH:16]1[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1)[C:6](O)=O)[CH3:2].C=O.N1CCCCC1>N1C=CC=CC=1>[CH2:1]([O:3][C:4](=[O:22])[C:5](=[CH2:6])[CH2:9][CH2:10][CH2:11][CH2:12][O:13][CH2:14][CH2:15][CH:16]1[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21]1)[CH3:2]

Participants

5

Reactant 3

HCID 712FormaldehydeHCID 8082PiperidineHCID 54345216HCID 54345216, compound

Product 1

HCID 53689540HCID 53689540, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

11.2 g of 6-(2-cyclohexylethoxy)-2-methylenehexanoic acid ethyl ester, in the form of a nearly colourless oil, which is purified by chromatography on silica gel (migrating agent: 9:1 petroleum ether/ethyl acetate), are obtained by the procedure described in Example 1b from 16.5 g of [4-(2-cyclohexylethoxy)-butyl]-malonic acid ethyl ester, 1.97 g of paraformaldehyde, 12 ml of pyridine and 0.7 ml of piperidine.

Workup

  1. custom11.2 g of 6-(2-cyclohexylethoxy)-2-methylenehexanoic acid ethyl ester, in the form of a nearly colourless oil, which is purified by chromatography on silica gel (migrating agent: 9:1 petroleum ether/ethyl acetate)
  2. customare obtained by the procedure

Sources & evidence

ORD record
ord-29986366f68a4bf1b49c3b2dc3db3f40
Source dataset
uspto-grants-1984_02
Patent number
US04430339

Reaction notes

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