HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formaldehyde → 8-Cyclopropyl-2-methyleneoctanoic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | (6-Cyclopropylhexyl)-malonic acid ethyl ester | HCID 54024252 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 8-Cyclopropyl-2-methyleneoctanoic acid ethyl ester | HCID 54308484 | — |
Reaction Steps
2.5 g of 8-cyclopropyl-2-methyleneoctanoic acid ethyl ester, in the form of a yellowish oil, which is purified by chromatography on silica gel (migrating agent: 90:10 petroleum ether/ethyl acetate), are obtained by the procedure described in Example (1b) from 4.53 g of (6-cyclopropylhexyl)-malonic acid ethyl ester 0.64 g of paraformaldehyde, 4 ml of pyridine and 0.2 ml of piperidine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04430339 |
| Source dataset | uspto-grants-1984_02 |
| ORD ID | ord-3f26fd22f769400da0a6802c1f6adace |
| Source note | uspto-grants-1984_02 |