Formaldehyde → HCID 54022117, compound

HRID 1388155Notes

Reaction equation

HRID 1388155 reaction equation
[CH2:1]([O:3][C:4](=[O:21])[CH:5]([CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH:14]1[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1)[C:6](O)=O)[CH3:2].C=O.N1CCCCC1>N1C=CC=CC=1>[CH2:1]([O:3][C:4](=[O:21])[C:5](=[CH2:6])[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH:14]1[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20]1)[CH3:2]

Participants

5

Reactant 3

HCID 712FormaldehydeHCID 8082PiperidineHCID 54236983HCID 54236983, compound

Product 1

HCID 54022117HCID 54022117, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

23.7 g of 7-cycloheptyl-2-methyleneheptanoic acid ethyl ester, in the form of a colourless oil, purified by chromatography on silica gel (migrating agent: 90:10 petroleum ether/ethyl acetate), are obtained by the procedure described in Example (1b) from 35 g of 5-cycloheptylpentylmalonic acid ethyl ester, 3,8 g of paraformaldehyde, 35 ml of pyridine and 1 g of piperidine.

Workup

  1. custom23.7 g of 7-cycloheptyl-2-methyleneheptanoic acid ethyl ester, in the form of a colourless oil, purified by chromatography on silica gel (migrating agent: 90:10 petroleum ether/ethyl acetate)
  2. customare obtained by the procedure

Sources & evidence

ORD record
ord-4b568333c8014470ba8c33da3174a2c1
Source dataset
uspto-grants-1984_02
Patent number
US04430339

Reaction notes

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