1-Methylpiperazine → HCID 3071000, compound

HRID 1388161Notes

Reaction equation

HRID 1388161 reaction equation
Cl[C:2]1[N:6]([CH2:7][CH2:8][O:9][CH2:10][C:11]#[CH:12])[C:5]2[CH:13]=[CH:14][CH:15]=[CH:16][C:4]=2[N:3]=1.[CH3:17][N:18]1[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]1.C(O)(=O)/C=C/C(O)=O>>[CH2:10]([O:9][CH2:8][CH2:7][N:6]1[C:5]2[CH:13]=[CH:14][CH:15]=[CH:16][C:4]=2[N:3]=[C:2]1[N:21]1[CH2:22][CH2:23][N:18]([CH3:17])[CH2:19][CH2:20]1)[C:11]#[CH:12]

Participants

4

Reactant 3

HCID 531671-MethylpiperazineHCID 444972Fumaric AcidHCID 15585274HCID 15585274, compound

Product 1

HCID 3071000HCID 3071000, compound

Procedure

In the same manner as described in Example 1 using 2-chloro-1-[2-(propargyloxy)ethyl]benzimidazole (3.00 g), N-methylpiperazine (2.70 g) and fumaric acid (1.52 g), there are obtained crude crystals, which are recrystallized from ethyl acetate-ethanol to give 1-[2-(propargyloxy)ethyl]-2-(4-methyl-1-piperazinyl)benzimidazole.3/2 fumarate (2.80 g) as colorless plates, m.p. 145°-146.5° C.

Workup

  1. customare obtained crude crystals, which
  2. customare recrystallized from ethyl acetate-ethanol

Sources & evidence

ORD record
ord-fe2610e78a6845eba7b4a683ba691a4a
Source dataset
uspto-grants-1984_02
Patent number
US04430343

Reaction notes

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