1-Methylpiperazine → HCID 3071002, compound

HRID 1388163Notes

Reaction equation

HRID 1388163 reaction equation
[CH2:1]([O:4][CH2:5][CH2:6][N:7]1[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=2[N:9]=[C:8]1Cl)[CH:2]=[CH2:3].[CH3:17][N:18]1[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]1.C(O)(=O)/C=C/C(O)=O>>[CH2:1]([O:4][CH2:5][CH2:6][N:7]1[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=2[N:9]=[C:8]1[N:21]1[CH2:22][CH2:23][N:18]([CH3:17])[CH2:19][CH2:20]1)[CH:2]=[CH2:3]

Participants

4

Reactant 3

HCID 531671-MethylpiperazineHCID 444972Fumaric AcidHCID 13623329HCID 13623329, compound

Product 1

HCID 3071002HCID 3071002, compound

Procedure

In the same manner as described in Example 1 using 1-[2-(allyloxy)ethyl]-2-chlorobenzimidazole (3.00 g), N-methylpiperazine (3.00 g) and fumaric acid (2.16 g), there are obtained crude crystals, which are recrystallized from ethyl acetate-ethanol to give 1-[2-(allyloxy)ethyl]-2-(4-methyl-1-piperazinyl)benzimidazole.3/2 fumarate (3.18 g) as colorless plates, m.p. 161.5°-164° C.

Workup

  1. customare obtained crude crystals, which
  2. customare recrystallized from ethyl acetate-ethanol

Sources & evidence

ORD record
ord-fa7767382a27440985eed14286ddebf2
Source dataset
uspto-grants-1984_02
Patent number
US04430343

Reaction notes

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