HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methylpiperazine → 1-(2-Ethoxyethyl)-2-(4-methylpiperazin-1-yl)benzimidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methylpiperazine | HCID 53167 | — |
| Reactant | Fumaric Acid | HCID 444972 | — |
| Reactant | 2-chloro-1-(2-ethoxyethyl)-1H-benzimidazole | HCID 10489356 | — |
| Product | 1-(2-Ethoxyethyl)-2-(4-methylpiperazin-1-yl)benzimidazole | HCID 3071004 | — |
Reaction Steps
In the same manner as described in Example 1 using 2-chloro-1-[2-(ethoxy)ethyl]benzimidazole (100.0 g), N-methylpiperazine (90.0 g) and fumaric acid (83.0 g), there are obtained crude crystals, which are recrystallized from ethanol to give 1-[2-(ethoxy)ethyl]-2-(4-methyl-1-piperazinyl)benzimidazole.3/2 fumarate (148.0 g) as colorless plates, m.p. 167.5°-168.5° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04430343 |
| Source dataset | uspto-grants-1984_02 |
| ORD ID | ord-fa7adbc4f5b44fc58f705828f7670876 |
| Source note | uspto-grants-1984_02 |