1-Methylpiperazine → 1-(2-ethoxyethyl)-2-(4-methylpiperazin-1-yl)benzimidazole

HRID 1388164Notes

Reaction equation

HRID 1388164 reaction equation
Cl[C:2]1[N:6]([CH2:7][CH2:8][O:9][CH2:10][CH3:11])[C:5]2[CH:12]=[CH:13][CH:14]=[CH:15][C:4]=2[N:3]=1.[CH3:16][N:17]1[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]1.C(O)(=O)/C=C/C(O)=O>>[CH2:10]([O:9][CH2:8][CH2:7][N:6]1[C:5]2[CH:12]=[CH:13][CH:14]=[CH:15][C:4]=2[N:3]=[C:2]1[N:20]1[CH2:21][CH2:22][N:17]([CH3:16])[CH2:18][CH2:19]1)[CH3:11]

Participants

4

Reactant 3

HCID 531671-MethylpiperazineHCID 444972Fumaric AcidHCID 104893562-chloro-1-(2-ethoxyethyl)-1H-benzimidazole

Product 1

HCID 30710041-(2-ethoxyethyl)-2-(4-methylpiperazin-1-yl)benzimidazole

Procedure

In the same manner as described in Example 1 using 2-chloro-1-[2-(ethoxy)ethyl]benzimidazole (100.0 g), N-methylpiperazine (90.0 g) and fumaric acid (83.0 g), there are obtained crude crystals, which are recrystallized from ethanol to give 1-[2-(ethoxy)ethyl]-2-(4-methyl-1-piperazinyl)benzimidazole.3/2 fumarate (148.0 g) as colorless plates, m.p. 167.5°-168.5° C.

Workup

  1. customare obtained crude crystals, which
  2. customare recrystallized from ethanol

Sources & evidence

ORD record
ord-fa7adbc4f5b44fc58f705828f7670876
Source dataset
uspto-grants-1984_02
Patent number
US04430343

Reaction notes

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