1-Methylhomopiperazine → 87233-68-9

HRID 1388165Notes

Reaction equation

HRID 1388165 reaction equation
[C:1]([O:5][CH2:6][CH2:7][N:8]1[C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=2[N:10]=[C:9]1Cl)(=O)[CH:2]=[CH2:3].[CH3:18][N:19]1[CH2:25][CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1.[C:26]([OH:33])(=[O:32])/[CH:27]=[CH:28]/[C:29]([OH:31])=[O:30]>>[C:26]([OH:33])(=[O:32])/[CH:27]=[CH:28]/[C:29]([OH:31])=[O:30].[C:26]([OH:33])(=[O:32])/[CH:27]=[CH:28]/[C:29]([OH:31])=[O:30].[CH2:1]([O:5][CH2:6][CH2:7][N:8]1[C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=2[N:10]=[C:9]1[N:22]1[CH2:23][CH2:24][CH2:25][N:19]([CH3:18])[CH2:20][CH2:21]1)[CH:2]=[CH2:3]

Participants

4

Reactant 3

HCID 2283491-MethylhomopiperazineHCID 444972Fumaric AcidHCID 70473518HCID 70473518, compound

Product 1

HCID 644842587233-68-9Yield 63.4%

Procedure

In the same manner as described in Example 1 using 1-[2-(alloyloxy)ethyl]-2-chlorobenzimidazole (4.00 g), N-methylhomopiperazine (4.00 g) and fumaric acid (2.58 g), there are obtained crude crystals, which are recrystallized from ethyl acetate-ethanol to give 1-[2-(allyloxy)ethyl]-2-(4-methyl-1-homopiperazinyl)benzimidazole difumarate (3.85 g) as colorless needles, m.p. 144.5°-146.5° C.

Workup

  1. customare obtained crude crystals, which
  2. customare recrystallized from ethyl acetate-ethanol

Sources & evidence

ORD record
ord-393d0b7053ba44fabec0ab49a38604ef
Source dataset
uspto-grants-1984_02
Patent number
US04430343

Reaction notes

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