Piperazine → HCID 3071008, compound

HRID 1388167Notes

Reaction equation

HRID 1388167 reaction equation
Cl[C:2]1[N:6]([CH2:7][CH2:8][O:9][CH2:10][CH3:11])[C:5]2[CH:12]=[CH:13][CH:14]=[CH:15][C:4]=2[N:3]=1.[NH:16]1[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]1.C(O)(=O)/C=C/C(O)=O>>[CH2:10]([O:9][CH2:8][CH2:7][N:6]1[C:5]2[CH:12]=[CH:13][CH:14]=[CH:15][C:4]=2[N:3]=[C:2]1[N:16]1[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]1)[CH3:11]

Participants

4

Reactant 3

HCID 4837PiperazineHCID 444972Fumaric AcidHCID 104893562-chloro-1-(2-ethoxyethyl)-1H-benzimidazole

Product 1

HCID 3071008HCID 3071008, compound

Procedure

In the same manner as described in Example 1 using 2-chloro-1-[2-(ethoxy)ethyl]benzimidazole (5.00 g), piperazine (19.00 g) and fumaric acid (3.19 g), there are obtained crude crystals, which are recrystallized from ethyl acetate-ethanol to give 1-[2-(ethoxy)ethyl]-2-(1-piperazinyl)benzimidazole.3/2 fumarate (2.29 g), as colorless needles, m.p. 167°-169° C.

Workup

  1. customare obtained crude crystals, which
  2. customare recrystallized from ethyl acetate-ethanol

Sources & evidence

ORD record
ord-63d67b42e22247cdabf1a3d68b999504
Source dataset
uspto-grants-1984_02
Patent number
US04430343

Reaction notes

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