1-Methylpiperazine → HCID 3071016, compound

HRID 1388171Notes

Reaction equation

HRID 1388171 reaction equation
Cl[C:2]1[N:6]([CH2:7][CH2:8][O:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[C:5]2[CH:16]=[CH:17][CH:18]=[CH:19][C:4]=2[N:3]=1.[CH3:20][N:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1.C(O)(=O)/C=C/C(O)=O>C(OCC)(=O)C.C(O)C>[O:9]([CH2:8][CH2:7][N:6]1[C:5]2[CH:16]=[CH:17][CH:18]=[CH:19][C:4]=2[N:3]=[C:2]1[N:24]1[CH2:25][CH2:26][N:21]([CH3:20])[CH2:22][CH2:23]1)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

Participants

5

Reactant 3

HCID 531671-MethylpiperazineHCID 444972Fumaric AcidHCID 13623331HCID 13623331, compound

Product 1

HCID 3071016HCID 3071016, compound

Reagents, catalysts & solvents 1

HCID 21584252Ethanol ethylacetateSolvent

Procedure

In the same manner as described in Example 1 using 2-chloro-1-[2-(phenoxy)ethyl]benzimidazole (3.00 g), N-methylpiperazine (3.00 g) and fumaric acid (2.14 g), there are obtained crude crystals, which are recrylstallized from ethyl acetate-ethanol to give 1-[2-(phenoxy)ethyl]-2-(4-methyl-1-piperazinyl)benzimidazole.3/2 fumarate (2.99 g) as pale yellow plates, m.p. 152°-153.5° C.

Workup

  1. customare obtained crude crystals, which

Sources & evidence

ORD record
ord-37cbefa61ca740d3867b268ddbf1fe15
Source dataset
uspto-grants-1984_02
Patent number
US04430343

Reaction notes

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