Phosphorus pentachloride → HCID 20471892, compound

HRID 1388191Notes

Reaction equation

HRID 1388191 reaction equation
[CH3:1][C:2]1[C:3]([C:12]([OH:14])=O)=[C:4]([S:8](=[O:11])(=[O:10])[NH2:9])[O:5][C:6]=1[CH3:7].P(Cl)(Cl)(Cl)(Cl)Cl>C1(C)C=CC=CC=1>[CH3:1][C:2]1[C:3]2[C:12](=[O:14])[NH:9][S:8](=[O:11])(=[O:10])[C:4]=2[O:5][C:6]=1[CH3:7]

Participants

4

Reactant 2

HCID 24819Phosphorus pentachlorideHCID 20471884HCID 20471884, compound

Product 1

HCID 20471892HCID 20471892, compoundYield 73.5%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A mixture of 1.0 gm (4.6 millimols) of 4.5-dimethyl-2-sulfamoyl-furan-3-carboxylic acid and 0.96 gm (4.6 millimols) of phosphorus pentachloride in toluene was reacted analogous to Example 1, yielding 0.68 gm (73% of theory) of 4,5-dimethylfuro[3,2-d]isothiazole-3-(2H)-one-1,1-dioxide. Rf -value: 0.21 (silica gel 60 F254 plates, thickness 0.25 mm, eluant ethylene chloride; ethyl acetate; glacial acetic acid 100:30:5).

Workup

  1. customwas reacted analogous to Example 1

Sources & evidence

ORD record
ord-f671b9d7415948d9a299a2197f6befc3
Source dataset
uspto-grants-1984_02
Patent number
US04430355

Reaction notes

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