Phosphorus pentachloride → HCID 20471892, compound

Participants

Reaction Steps

A mixture of 1.0 gm (4.6 millimols) of 4.5-dimethyl-2-sulfamoyl-furan-3-carboxylic acid and 0.96 gm (4.6 millimols) of phosphorus pentachloride in toluene was reacted analogous to Example 1, yielding 0.68 gm (73% of theory) of 4,5-dimethylfuro[3,2-d]isothiazole-3-(2H)-one-1,1-dioxide. Rf -value: 0.21 (silica gel 60 F254 plates, thickness 0.25 mm, eluant ethylene chloride; ethyl acetate; glacial acetic acid 100:30:5).

Provenance & Evidence