Hydrochloric Acid → 2-Chloromethylbenzofuran

HRID 1388299Notes

Reaction equation

HRID 1388299 reaction equation
[ClH:1].[CH2:2]=O.[CH:4]1[CH:9]=[C:8]2[CH:10]=[CH:11][O:12][C:7]2=[CH:6][CH:5]=1>C1C=CC=CC=1>[Cl:1][CH2:2][C:11]1[O:12][C:7]2[CH:6]=[CH:5][CH:4]=[CH:9][C:8]=2[CH:10]=1

Participants

5

Reactant 3

HCID 313Hydrochloric Acid2×HCID 712FormaldehydeHCID 9223Benzofuran

Product 1

HCID 1843482-Chloromethylbenzofuran

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

A 1 l R.B. flask was equipped with a mechanical stirrer, addition funnel, and gas inlet tube. The flask was charged with 212 ml of conc. HCl, 127 ml of benzene, and 38.14 g of paraformaldehyde, then cooled to 0° C. and saturated with hydrogen chloride gas. While maintaining the temperature at 0°-1° C. add the 50.0 g (0.423 mol) of 2,3-benzofuran in a slow dropwise fashion. When the addition was complete, the mixture was stirred 21/2-3 hours at room temperature.

Workup

  1. customflask was equipped with a mechanical stirrer, addition funnel, and gas inlet tube
  2. temperatureWhile maintaining the temperature at 0°-1° C.
  3. additionWhen the addition

Sources & evidence

ORD record
ord-b59d4a98dbe544ca9b5fdf45d1e13b2a
Source dataset
uspto-grants-1984_02
Patent number
US04431650

Reaction notes

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