Sodium Carbonate → HCID 20470932, compound

HRID 1388353Notes

Reaction equation

HRID 1388353 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:9]23[C:15](=[O:16])[CH2:14][CH:13]2[CH2:12][NH:11][CH2:10]3)[CH:6]=[CH:7][CH:8]=1.[CH:17]1([CH2:20]Br)[CH2:19][CH2:18]1.C(=O)([O-])[O-].[Na+].[Na+]>C1(C)C=CC=CC=1>[CH:17]1([CH2:20][N:11]2[CH2:10][C:9]3([C:5]4[CH:6]=[CH:7][CH:8]=[C:3]([O:2][CH3:1])[CH:4]=4)[CH:13]([CH2:14][C:15]3=[O:16])[CH2:12]2)[CH2:19][CH2:18]1

Participants

5

Reactant 3

HCID 10340Sodium CarbonateHCID 81503BromomethylcyclopropaneHCID 20470943HCID 20470943, compound

Product 1

HCID 20470932HCID 20470932, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

In the manner of Example 8, 5-(m-methoxyphenyl)-3-azabicyclo[3.2.0]heptan-6-one, dimethyl acetal, can be reacted with cyclopropylmethyl bromide and sodium carbonate in toluene to give 3-cyclopropylmethyl-5-(m-methoxyphenyl)-3-azabicyclo[3.2.0]heptan-6-one, dimethyl acetal.

Sources & evidence

ORD record
ord-88d2e387ca164452bb2eb8537410566d
Source dataset
uspto-grants-1984_02
Patent number
US04431661

Reaction notes

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