Hydrochloric Acid → HCID 131712736, compound

HRID 1388483Notes

Reaction equation

HRID 1388483 reaction equation
[CH2:1]([O:4][N:5]=[C:6]([C:27]1[N:28]=[C:29]([NH:32]C=O)[S:30][CH:31]=1)[C:7]([NH:9][CH:10]1[C:25](=[O:26])[N:12]2[C:13]([C:22]([OH:24])=[O:23])=[C:14]([CH2:17][O:18][C:19](=[O:21])[NH2:20])[CH2:15][S:16][C@H:11]12)=[O:8])[CH2:2][CH3:3].[ClH:35]>CO>[ClH:35].[CH2:1]([O:4][N:5]=[C:6]([C:27]1[N:28]=[C:29]([NH2:32])[S:30][CH:31]=1)[C:7]([NH:9][CH:10]1[C:25](=[O:26])[N:12]2[C:13]([C:22]([OH:24])=[O:23])=[C:14]([CH2:17][O:18][C:19](=[O:21])[NH2:20])[CH2:15][S:16][C@H:11]12)=[O:8])[CH2:2][CH3:3]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 131712738HCID 131712738, compound

Product 1

HCID 131712736HCID 131712736, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

7-[2-Propoxyimino-2-(2-formamido-1,3-thiazol-4-yl)acetamido]-3-carbamoyloxymethyl-3-cephem-4-carboxylic acid (syn isomer)(0.5 g) was suspended in methanol (15 ml). To the suspension was added conc. hydrochloric acid (0.2 ml) and the mixture was stirred for 2 hours at ambient temperature. The reaction mixture was concentrated and the residue was washed with tetrahydrofuran, collected by filtration and dried to give 7-[2-propoxyimino-2-(2-amino-1,3-thiazol-4-yl)acetamido]-3-carbamoyloxymethyl-3-cephem-4-carboxylic acid hydrochloride (syn isomer)(0.4 g).

Workup

  1. concentrationThe reaction mixture was concentrated
  2. washthe residue was washed with tetrahydrofuran
  3. filtrationcollected by filtration
  4. customdried

Sources & evidence

ORD record
ord-634216c30f57403aac1b5878ba2a27fc
Source dataset
uspto-grants-1984_02
Patent number
US04431643

Reaction notes

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