反应详情

温度

80 °C

A solution of 216.2 g of sodium ethylxanthate in 250 ml of dimethylformamide is added dropwise to a solution, heated to 140°-150° C., of 63.8 g of 2-chloroaniline in 150 ml of dimethylformamide in the course of one hour, under a nitrogen atmosphere. During this addition, the internal temperature is kept at 150° C. by removing some of the distillate. The reaction mixture is then subsequently stirred under reflux for about 12 hours, cooled to about 80° C. and stirred into 1.2 l of ice-water. The resulting cloudy solution is acidified and the 2-mercaptobenzothiazole which has precipitated is filtered off. After washing and drying, 79 g (94.6% of theory) of 2-mercaptobenzothiazole of melting point 179°-180° C. are obtained.

1. additionDuring this addition
2. customis kept at 150° C.
3. customby removing some of the distillate
4. temperatureunder reflux for about 12 hours
5. stirringstirred into 1.2 l of ice-water
6. customthe 2-mercaptobenzothiazole which has precipitated
7. filtrationis filtered off
8. washAfter washing
9. customdrying