Ammonium Hydroxide → HCID 13282892, compound

HRID 1388519Notes

Reaction equation

HRID 1388519 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([CH:12]([OH:18])[C:13](OCC)=[O:14])[CH:11]=1)[N:8]=[CH:7][CH:6]=[CH:5]2.[OH-].[NH4+:20]>>[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([CH:12]([OH:18])[C:13]([NH2:20])=[O:14])[CH:11]=1)[N:8]=[CH:7][CH:6]=[CH:5]2

Participants

3

Reactant 2

HCID 14923Ammonium HydroxideHCID 13560092Ethyl 2-(6-fluoro-8-quinolyl)-2-hydroxyacetate

Product 1

HCID 13282892HCID 13282892, compound

Procedure

Ethyl 2-(6-fluoro-8-quinolyl)-2-hydroxyacetate (1.1 g.) was refluxed for 10 minutes in 300 ml. of conc. ammonium hydroxide. The reaction mixture was cooled slightly, clarified by filtration and evaporated to solids. Trituration of the residue with 25 ml. of toluene gave the title product (860 mg., m.p. 169°-171° C.).

Workup

  1. temperatureThe reaction mixture was cooled slightly
  2. filtrationclarified by filtration
  3. customevaporated to solids

Sources & evidence

ORD record
ord-d523683b85dc491fb8e7491996d6c8a4
Source dataset
uspto-grants-1984_02
Patent number
US04431810

Reaction notes

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