反应详情

Sodium borohydride (1.67 g) was added in portions to a solution of 6-fluoro-2-tetralone (6.56 g) in dry ethanol (30 ml) with stirring, keeping the temperature below 25° C. The mixture was then stirred at room temperature for 3 hours. The mixture was then diluted with a little ethyl acetate and concentrated to an oily residue. Dilute sulphuric acid was added dropwise until effervescence no longer occurred. The mixture was extracted with ether and the extract washed, dried, and concentrated to give an oil. This was distilled (b.p. 75-77/0.1 Torr) to give 6-fluorotetralin-2-ol (5.31 g) containing a trace of the tetralone starting material.

1. customthe temperature below 25° C
2. stirringThe mixture was then stirred at room temperature for 3 hours
3. concentrationconcentrated to an oily residue
4. additionDilute sulphuric acid was added dropwise until effervescence
5. extractionThe mixture was extracted with ether
6. washthe extract washed
7. customdried
8. concentrationconcentrated
9. customto give an oil
10. distillationThis was distilled (b.p. 75-77/0.1 Torr)