Glycerol → HCID 20469345, compound

Participants

Reaction Steps

0.1 mol (17.3 g) of 3-amino-4-nitro-chlorobenzene, which is a known compound [Bios Final Report, 1,147 (1948)], is introduced gradually, at about 120° C., whilst stirring, into 2.4 mols (225 g) of glycerol in which 8.6 g of sodium hydroxide have been dissolved beforehand at about 120° C. When the addition has ended, heating is continued for 21/2 hours and the reaction medium is then poured into 250 g of iced water. The desired product is extracted with ethyl acetate and the ethyl acetate is driven off in vacuo to give 13.6 g of crystalline product. After two recrystallisations from acetonitrile and drying in vacuo, 3-amino-4-nitrophenyl β,γ-dihydroxypropyl ether, which melts at 139° C., is collected.

Provenance & Evidence