Hydrogen Bromide → HCID 14655653, compound

HRID 1388641Notes

Reaction equation

HRID 1388641 reaction equation
[CH2:1]([O:3][C:4](=[O:28])[C@H:5]([CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)[NH:6][C:7](=[O:20])[CH2:8][NH:9]C(OCC1C=CC=CC=1)=O)[CH3:2].Br>CCOCC>[CH2:1]([O:3][C:4](=[O:28])[C@H:5]([CH2:21][C:22]1[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=1)[NH:6][C:7](=[O:20])[CH2:8][NH2:9])[CH3:2]

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 11696672HCID 11696672, compound

Product 1

HCID 14655653HCID 14655653, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

The deposit was filtered off by a glass filter, and after the filtrate was washed with a 0.1% aqueous solution of NaHCO3 three times and then washed with a 0.1 N aqueous solution of HCl three times, it was dried over anhydrous magnesium sulfate and freed of dichloromethane under reduced pressure to obtain carbobenzoxyglycyl-L-phenylalanine ethyl ester, and to this ester was added 250 ml of HBr-saturated acetic acid, and after the mixture was stirred for 30 minutes, anhydrous ether was added to the mixture to produce a precipitate. The filtered off precipitate was washed with ether to obtain glycyl-L-phenylalanine ethyl ester.HBr.

Workup

  1. customto produce a precipitate
  2. filtrationThe filtered off precipitate
  3. washwas washed with ether

Sources & evidence

ORD record
ord-fd26c99e92cb4086af986b34146d33c6
Source dataset
uspto-grants-1984_02
Patent number
US04432896

Reaction notes

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