Hydrochloric Acid → 3-Methoxy-2-naphthoic acid

HRID 1388674Notes

Reaction equation

HRID 1388674 reaction equation
[CH3:1][O:2][C:3]1[C:4]([C:13]([O:15]C)=[O:14])=[CH:5][C:6]2[C:11]([CH:12]=1)=[CH:10][CH:9]=[CH:8][CH:7]=2.Cl>[OH-].[Na+]>[CH3:1][O:2][C:3]1[C:4]([C:13]([OH:15])=[O:14])=[CH:5][C:6]2[C:11]([CH:12]=1)=[CH:10][CH:9]=[CH:8][CH:7]=2

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 296952Methyl 3-Methoxy-2-naphthoate

Product 1

HCID 701613-Methoxy-2-naphthoic acid

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

The methyl 3-methoxy-2-naphthoate was diluted with excess 5 percent sodium hydroxide solution and the mixture was heated at its reflux temperature until the solution was clear. The solution was acidified with hydrochloric acid to provide a precipitate which was separated by filtration. Recrystallization from benzene provided the known intermediate 3-methoxy-2-naphthoic acid, m.p. 130°-132° C.

Workup

  1. temperaturethe mixture was heated at its
  2. temperaturereflux temperature until the solution
  3. customto provide a precipitate which
  4. customwas separated by filtration
  5. customRecrystallization from benzene

Sources & evidence

ORD record
ord-634c7d010f1343fd93c843b7f471d4fd
Source dataset
uspto-grants-1984_02
Patent number
US04432986

Reaction notes

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