HCID 131713396, compound → HCID 54132603, compound

HRID 1388692Notes

Reaction equation

HRID 1388692 reaction equation
[CH2:1]([O:3][P:4]([CH2:33][C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1)([NH:6][C@H:7]([C:15]([NH:17][C@H:18]([C:23]([O:25]CC1C=CC=CC=1)=[O:24])[CH2:19][CH:20]([CH3:22])[CH3:21])=[O:16])[CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)=[O:5])[CH3:2]>CO.[C].[Pd]>[CH2:1]([O:3][P:4]([CH2:33][C:34]1[CH:35]=[CH:36][CH:37]=[CH:38][CH:39]=1)([NH:6][C@H:7]([C:15]([NH:17][C@H:18]([C:23]([OH:25])=[O:24])[CH2:19][CH:20]([CH3:22])[CH3:21])=[O:16])[CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)=[O:5])[CH3:2]

Participants

4

Reactant 1

HCID 131713396HCID 131713396, compound

Product 1

HCID 54132603HCID 54132603, compound

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

A solution of the ester product from part (b) in methanol is treated with 10% palladium-carbon catalyst and hydrogenated in a Parr apparatus at an initial pressure of 45 psi. for 1.5 hours. The mixture is filtered through Celite and evaporated to dryness to give N-[N-[ethoxy(phenylmethyl)phosphinyl]-L-phenylalanyl]-L-leucine.

Workup

  1. filtrationThe mixture is filtered through Celite
  2. customevaporated to dryness

Sources & evidence

ORD record
ord-568e055cade7457483ad66eeea2e32a2
Source dataset
uspto-grants-1984_02
Patent number
US04432972

Reaction notes

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