HRID1388696

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID24654

Hydrazine hydrate (1:1)

H6N2O

结构：CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NP(=O)(CCCCCCN1C(=O)c2ccccc2C1=O)OCc1ccccc1)C(=O)OCc1ccccc1

HCID131713400

未命名化合物

PRODUCTS

生成物

结构：CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)N(OCc1ccccc1)[PH](=O)CCCCCCN)C(=O)OCc1ccccc1

HCID178445954

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID1140

Toluene

C7H8

溶剂HCID31275

1,4-Dioxane

C4H8O2

PROCEDURE

实验过程

A solution of N-[N-[(phenylmethoxy)(6-phthalimidohexyl)phosphinyl]-L-phenylalanyl]-L-leucine, phenylmethyl ester in dioxane is treated with hydrazine hydrate and stirred at room temperature under argon. After 24 hours, the mixture is diluted with toluene and the solvents decanted and evaporated to dryness. The residue is purified by extraction and flash chromatography to give N-[(phenylmethoxy)[(6-aminohexyl)phosphinyl]-L-phenylalanyl]-L-leucine, phenylmethyl ester.

WORKUP

后处理

customthe solvents decanted
customevaporated to dryness
customThe residue is purified by extraction and flash chromatography

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-07a9cdcedfed4f8f87c781cadbc40ceb
来源数据集: uspto-grants-1984_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04432972
来源说明: uspto-grants-1984_02

反应 SMILES

C1(C[O:8][P:9]([CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][CH2:43][N:44]2C(=O)C3=CC=CC=C3C2=O)([NH:11][C@H:12]([C:20]([NH:22][C@H:23]([C:28]([O:30][CH2:31][C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)=[O:29])[CH2:24][CH:25]([CH3:27])[CH3:26])=[O:21])[CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=O)C=CC=CC=1.[OH2:55].NN>O1CCOCC1.C1(C)C=CC=CC=1>[C:14]1([CH2:13][O:55][N:11]([PH:9]([CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][CH2:43][NH2:44])=[O:8])[C@H:12]([C:20]([NH:22][C@H:23]([C:28]([O:30][CH2:31][C:32]2[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=2)=[O:29])[CH2:24][CH:25]([CH3:27])[CH3:26])=[O:21])[CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1