反应详情

A mixture of 2-benzofuran glyoxal (10.44 g) and 2-amino-3-(4-methylphenyl)propane (8.94 g) was refluxed in benzene using a Dean and Stark head until the theoretical amount of water had been removed. The solvent was evaporated, replaced with methanol and sodium borohydride (5 g) added. The methanol was evaporated, the residue partitioned between water and ether and the ether layer dried. Filtration and evaporation gave an oil which was chromatographed on Kieselgel 60. Elution with 2% methanol-chloroform gave N-[2-(4-methylphenyl)-1-methylethyl]-2-(2-benzofuranyl)-2-hydroxyethanamine (14 g).

1. customhad been removed
2. customThe solvent was evaporated
3. additionadded
4. customThe methanol was evaporated
5. customthe residue partitioned between water and ether
6. dry with materialthe ether layer dried
7. filtrationFiltration and evaporation
8. customgave an oil which
9. customwas chromatographed on Kieselgel 60
10. washElution with 2% methanol-chloroform