Methanol → HCID 20470047, compound

HRID 1388743Notes

Reaction equation

HRID 1388743 reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[CH:3]=[C:2]1[CH:10](O)[CH2:11][NH2:12].[CH3:14][O:15][C:16]1[CH:21]=[CH:20][C:19]([CH2:22][C:23](=O)[CH3:24])=[CH:18][CH:17]=1.CO.CC[O:30]CC.CCCCCC>ClCCl>[CH3:14][O:15][C:16]1[CH:21]=[CH:20][C:19]([CH2:22][CH:23]([NH:12][CH:11]([OH:30])[CH2:10][C:2]2[O:1][C:5]3[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=3[CH:3]=2)[CH3:24])=[CH:18][CH:17]=1

Participants

6

Reactant 4

HCID 887MethanolHCID 312311-(p-Methoxyphenyl)-2-propanoneHCID 128143572-Amino-1-(1-benzofuran-2-yl)ethan-1-olHCID 21584099Diethylether hexane

Product 1

HCID 20470047HCID 20470047, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

This compound was prepared in an identical manner to the compound described in Example 2 using 2-(2-benzofuranyl)-2-hydroxyethanamine (1.65 g) and 1-(4-methoxyphenyl)propan-2-one (1.53 g). Chromatography of the residual oil on Kieselgel 60 (4% methanol in dichloromethane) gave the title compound, m.p. 75°-85° (Et2O-hexane) as a 44:56 mixture of diastereoisomers.

Workup

  1. customThis compound was prepared in an identical manner to the compound

Sources & evidence

ORD record
ord-bb6872caa1094bfd9808ecc701273d86
Source dataset
uspto-grants-1984_02
Patent number
US04432993

Reaction notes

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