4-Chloro-1,2-dinitrobenzene → ethyl P-methyl-2-nitro-5-chlorophenylphosphinate

HRID 1388773Notes

Reaction equation

HRID 1388773 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[C:4]([N+]([O-])=O)[CH:3]=1.[CH3:14][P:15]([O:19]CC)[O:16][CH2:17][CH3:18]>C(#N)C>[CH3:14][P:15]([C:4]1[CH:3]=[C:2]([Cl:1])[CH:7]=[CH:6][C:5]=1[N+:8]([O-:10])=[O:9])(=[O:19])[O:16][CH2:17][CH3:18]

Participants

4

Reactant 2

HCID 330974-Chloro-1,2-dinitrobenzeneHCID 85063Diethyl methylphosphonite

Product 1

HCID 53860251ethyl P-methyl-2-nitro-5-chlorophenylphosphinate

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A mixture of 4-chloro-1,2-dinitrobenzene (3.31 mmol) and diethyl methylphosphonite (5.30 mmol) in 3 ml of acetonitrile is stirred at RT overnight. The mixture is then concentrated and the residue is purified by preparative TLC to yield ethyl P-methyl-2-nitro-5-chlorophenylphosphinate.

Workup

  1. concentrationThe mixture is then concentrated
  2. customthe residue is purified by preparative TLC

Sources & evidence

ORD record
ord-e2e7d7f07a43420d9a75798be362e9dc
Source dataset
uspto-grants-1984_02
Patent number
US04433149

Reaction notes

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